The Most Advanced Genetic Testing for Your Embryos
Next Generation Sequencing (NGS) is a cutting-edge genetic technology that allows comprehensive chromosomal analysis of embryos before they are transferred. By identifying chromosomally normal embryos, NGS significantly increases the chance of a successful pregnancy and reduces the risk of miscarriage or chromosomal conditions such as Down syndrome.
How NGS Works
During an IVF cycle, a small biopsy of cells is taken from each embryo at the blastocyst stage (day 5 or 6). These cells are sent to a specialist genetics laboratory where NGS technology analyses all 24 chromosomes simultaneously. Results are typically available within 7-14 days, after which normal embryos are selected for transfer in a frozen embryo transfer cycle.
Key Benefits of Next Generation Sequencing (NGS)
- Analyses all 24 chromosomes simultaneously
- Higher accuracy than older genetic testing methods
- Reduces the risk of miscarriage significantly
- Increases live birth rates per transfer
- Helps identify the most viable embryo for transfer
Who Is a Good Candidate for Next Generation Sequencing (NGS)?
- Women aged 35 and over
- Couples with a history of recurrent miscarriage
- Those with previous failed IVF cycles
- Couples with known chromosomal abnormalities
- Anyone seeking the highest possible chance of success from each transfer
NGS Testing Timeline
Day 1-12
Ovarian stimulation and monitoring. Egg retrieval at optimal time.
Day 5-6
Embryos reach blastocyst stage. Biopsy taken from each suitable embryo.
Week 1-2
Biopsied cells sent to genetics lab. Embryos vitrified while awaiting results.
Week 2-3
NGS results received. Chromosomally normal embryos identified.
FET Cycle
Endometrial preparation begins. Transfer date scheduled.
2 Weeks Post-Transfer
Pregnancy test. NGS-tested embryos offer higher confidence in each transfer.
Frequently Asked Questions About NGS
NGS is the technology used to perform PGT-A. NGS is more accurate and comprehensive than older array-CGH methods, analysing the entire genome in greater detail.
The biopsy is performed by highly trained embryologists and is considered safe. Biopsied embryos that are chromosomally normal develop and implant at the same rate as unbiopsied embryos.
NGS detects chromosomal abnormalities but does not screen for all single-gene disorders. Additional PGT-M testing is needed for specific inherited conditions.
Results are typically available within 7-14 days. During this time, your embryos are safely vitrified and stored.